Validating the fragment-based drug discovery strategy for targeting biological RNAs: Lead fragments specifically bind and remodel the TPP riboswitch

Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Previous studies using fragment-based approaches identified small molecule “fragments” that bind this gene-regulatory mRNA domain. Crystallographic studies now show...

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Detalhes bibliográficos
Main Authors: Warner, Katherine Deigan, Homan, Philip, Weeks, Kevin M., Smith, Alison G., Abell, Chris, Ferré-D’Amaré, Adrian R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057041/
https://ncbi.nlm.nih.gov/pubmed/24768306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.03.007
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