Validating the fragment-based drug discovery strategy for targeting biological RNAs: Lead fragments specifically bind and remodel the TPP riboswitch

Eitemau Tebyg

• Crystallographic analysis of TPP riboswitch binding by small molecule ligands discovered through fragment-based drug discovery approaches
  gan: Warner, Katherine Deigan, et al.
  Cyhoeddwyd: (2014)
• Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs
  gan: Deigan, Katherine E., et al.
  Cyhoeddwyd: (2011)
• Structure and mechanism of the T-box riboswitches
  gan: Zhang, Jinwei, et al.
  Cyhoeddwyd: (2015)
• THE ROLES OF METAL IONS IN REGULATION BY RIBOSWITCHES
  gan: Ferré-D'Amaré, Adrian, et al.
  Cyhoeddwyd: (2011)
• Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules
  gan: Ferré-D'Amaré, Adrian R.
  Cyhoeddwyd: (2011)