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The Use of Mitochondria-Targeted Endonucleases to Manipulate mtDNA
For more than a decade, mitochondria-targeted nucleases have been used to promote double-strand breaks in the mitochondrial genome. This was done in mitochondrial DNA (mtDNA) homoplasmic systems, where all mtDNA molecules can be affected, to create models of mitochondrial deficiencies. Alternatively...
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| Veröffentlicht in: | Methods Enzymol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4274129/ https://ncbi.nlm.nih.gov/pubmed/25416366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-801415-8.00018-7 |
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