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The Use of Mitochondria-Targeted Endonucleases to Manipulate mtDNA

For more than a decade, mitochondria-targeted nucleases have been used to promote double-strand breaks in the mitochondrial genome. This was done in mitochondrial DNA (mtDNA) homoplasmic systems, where all mtDNA molecules can be affected, to create models of mitochondrial deficiencies. Alternatively...

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Publicat a:Methods Enzymol
Autors principals: Bacman, Sandra R., Williams, Sion L., Pinto, Milena, Moraes, Carlos T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274129/
https://ncbi.nlm.nih.gov/pubmed/25416366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-801415-8.00018-7
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