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Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling
TGF-β signaling is essential in many processes, including immune surveillance, and its dysregulation controls various diseases, including cancer, fibrosis, and inflammation. Studying the innate host defense, which functions in most cell types, we found that RLR signaling represses TGF-β responses. T...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4273650/ https://ncbi.nlm.nih.gov/pubmed/25526531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.027 |
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