Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling

TGF-β signaling is essential in many processes, including immune surveillance, and its dysregulation controls various diseases, including cancer, fibrosis, and inflammation. Studying the innate host defense, which functions in most cell types, we found that RLR signaling represses TGF-β responses. T...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Xu, Pinglong, Bailey-Bucktrout, Samantha, Xi, Ying, Xu, Daqi, Du, Dan, Zhang, Qian, Xiang, Weiwen, Liu, Jianming, Melton, Andrew, Sheppard, Dean, Chapman, Harold A., Bluestone, Jeffrey A., Derynck, Rik
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273650/
https://ncbi.nlm.nih.gov/pubmed/25526531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.027
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