Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling

TGF-β signaling is essential in many processes, including immune surveillance, and its dysregulation controls various diseases, including cancer, fibrosis, and inflammation. Studying the innate host defense, which functions in most cell types, we found that RLR signaling represses TGF-β responses. T...

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Pubblicato in:Mol Cell
Autori principali: Xu, Pinglong, Bailey-Bucktrout, Samantha, Xi, Ying, Xu, Daqi, Du, Dan, Zhang, Qian, Xiang, Weiwen, Liu, Jianming, Melton, Andrew, Sheppard, Dean, Chapman, Harold A., Bluestone, Jeffrey A., Derynck, Rik
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273650/
https://ncbi.nlm.nih.gov/pubmed/25526531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.027
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