Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening host survival on the one hand but allowing faster transmission on the other...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Payne, Rebecca, Muenchhoff, Maximilian, Mann, Jaclyn, Roberts, Hannah E., Matthews, Philippa, Adland, Emily, Hempenstall, Allison, Huang, Kuan-Hsiang, Brockman, Mark, Brumme, Zabrina, Sinclair, Marc, Miura, Toshiyuki, Frater, John, Essex, Myron, Shapiro, Roger, Walker, Bruce D., Ndung’u, Thumbi, McLean, Angela R., Carlson, Jonathan M., Goulder, Philip J. R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273423/
https://ncbi.nlm.nih.gov/pubmed/25453107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413339111
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