Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening host survival on the one hand but allowing faster transmission on the other...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Payne, Rebecca, Muenchhoff, Maximilian, Mann, Jaclyn, Roberts, Hannah E., Matthews, Philippa, Adland, Emily, Hempenstall, Allison, Huang, Kuan-Hsiang, Brockman, Mark, Brumme, Zabrina, Sinclair, Marc, Miura, Toshiyuki, Frater, John, Essex, Myron, Shapiro, Roger, Walker, Bruce D., Ndung’u, Thumbi, McLean, Angela R., Carlson, Jonathan M., Goulder, Philip J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273423/
https://ncbi.nlm.nih.gov/pubmed/25453107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413339111
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