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Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics

Many cancers have substantial genomic heterogeneity within a given tumor, and to fully understand that diversity requires the ability to perform single cell analysis. We performed targeted sequencing of a panel of single nucleotide variants (SNVs), deletions, and IgH sequences in 1,479 single tumor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gawad, Charles, Koh, Winston, Quake, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273416/
https://ncbi.nlm.nih.gov/pubmed/25425670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420822111
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