OX40- and CD27-mediated co-stimulation synergize with anti-PD-L1 blockade by forcing exhausted CD8(+) T cells to exit quiescence

Exhaustion of chronically stimulated CD8(+) T cells is a significant obstacle to immune control of chronic infections or tumors. Although co-inhibitory checkpoint blockade with anti-programmed death-ligand 1 (PD-L1) antibody can restore functions to exhausted T cell populations, recovery is often in...

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Publicado no:J Immunol
Main Authors: Buchan, Sarah, Manzo, Teresa, Flutter, Barry, Rogel, Anne, Edwards, Noha, Zhang, Lei, Sivakumaran, Shivajanani, Ghorashian, Sara, Carpenter, Ben, Bennett, Clare, Freeman, Gordon J., Sykes, Megan, Croft, Michael, Al-Shamkhani, Aymen, Chakraverty, Ronjon
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272895/
https://ncbi.nlm.nih.gov/pubmed/25404365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401644
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