Nonhematopoietic antigen blocks memory programming of alloreactive CD8(+) T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) responses. The major reason for treatment failure is...

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Auteurs principaux: Flutter, Barry, Edwards, Noha, Fallah-Arani, Farnaz, Henderson, Stephen, Chai, Jian-Guo, Sivakumaran, Shivajanani, Ghorashian, Sara, Bennett, Clare L., Freeman, Gordon J., Sykes, Megan, Chakraverty, Ronjon
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964967/
https://ncbi.nlm.nih.gov/pubmed/20978352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41446
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