Nonhematopoietic antigen blocks memory programming of alloreactive CD8(+) T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) responses. The major reason for treatment failure is...

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Detalhes bibliográficos
Main Authors: Flutter, Barry, Edwards, Noha, Fallah-Arani, Farnaz, Henderson, Stephen, Chai, Jian-Guo, Sivakumaran, Shivajanani, Ghorashian, Sara, Bennett, Clare L., Freeman, Gordon J., Sykes, Megan, Chakraverty, Ronjon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964967/
https://ncbi.nlm.nih.gov/pubmed/20978352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41446
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