Depletion of CD11c(+) cells in the CD11c.DTR model drives expansion of unique CD64(+) Ly6C(+) monocytes that are poised to release TNF-α

Dendritic cells (DCs) play a vital role in innate and adaptive immunities. Inducible depletion of CD11c(+) DCs engineered to express a high-affinity diphtheria toxin receptor has been a powerful tool to dissect DC function in vivo. However, despite reports showing that loss of DCs induces transient...

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Détails bibliographiques
Publié dans:Eur J Immunol
Auteurs principaux: Sivakumaran, Shivajanani, Henderson, Stephen, Ward, Sophie, Santos E Sousa, Pedro, Manzo, Teresa, Zhang, Lei, Conlan, Thomas, Means, Terry K, D'Aveni, Maud, Hermine, Olivier, Rubio, Marie-Thérèse, Chakraverty, Ronjon, Bennett, Clare L
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Ltd 2016
Sujets:
Innate Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722854/
https://ncbi.nlm.nih.gov/pubmed/26464217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545789
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