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Nonhematopoietic antigen blocks memory programming of alloreactive CD8(+) T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation
Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) responses. The major reason for treatment failure is...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964967/ https://ncbi.nlm.nih.gov/pubmed/20978352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41446 |
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