Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways

Non-resolving inflammation expands a heterogeneous population of myeloid suppressor cells capable of inhibiting T cell function. This heterogeneity has confounded the functional dissection of individual myeloid subpopulations and presents an obstacle for anti-tumor immunity and immunotherapy. Using...

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Publicado no:Immunity
Main Authors: Haverkamp, Jessica M., Smith, Amber M., Weinlich, Ricardo, Dillon, Christopher P., Qualls, Joseph E., Neale, Geoffrey, Koss, Brian, Kim, Young, Bronte, Vincenzo, Herold, Marco J., Green, Douglas R., Opferman, Joseph T., Murray, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272664/
https://ncbi.nlm.nih.gov/pubmed/25500368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.10.020
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