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Intrinsic and extrinsic noise of gene expression in lineage trees

Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the population dynamics. While these sources are usually studied separately, we develop an agent-based framework that accounts for both factors while tracking every single cell of a growing population. Apart from th...

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Publicat a:Sci Rep
Autor principal: Thomas, Philipp
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345792/
https://ncbi.nlm.nih.gov/pubmed/30679440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35927-x
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