SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this dise...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Autores principales: Gerby, Bastien, Tremblay, Cedric S., Tremblay, Mathieu, Rojas-Sutterlin, Shanti, Herblot, Sabine, Hébert, Josée, Sauvageau, Guy, Lemieux, Sébastien, Lécuyer, Eric, Veiga, Diogo F. T., Hoang, Trang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270438/
https://ncbi.nlm.nih.gov/pubmed/25522233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004768
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