Ldb1 is required for Lmo2 oncogene–induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia

Prolonged or enhanced expression of the proto-oncogene Lmo2 is associated with a severe form of T-cell acute lymphoblastic leukemia (T-ALL), designated early T-cell precursor ALL, which is characterized by the aberrant self-renewal and subsequent oncogenic transformation of immature thymocytes. It h...

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Pubblicato in:Blood
Autori principali: Li, LiQi, Mitra, Apratim, Cui, Kairong, Zhao, Bin, Choi, Seeyoung, Lee, Jan Y., Stamos, Daniel B., El-Khoury, Dalal, Warzecha, Claude, Pfeifer, Karl, Hardwick, Joyce, Zhao, Keji, Venters, Bryan, Davé, Utpal P., Love, Paul E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316212/
https://ncbi.nlm.nih.gov/pubmed/32181817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000794
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