Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer in Vitro and in Vivo Via Exacerbating Unfolded Protein Responses

PURPOSE: Ovarian cancer is the deadliest of the gynecological malignancies. Carcinogenic progression is accompanied by up-regulation of ubiquitin-dependent protein degradation machinery as a mechanism to compensate with elevated endogenous proteotoxic stress. Recent studies support the notion that d...

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Publicado no:Clin Cancer Res
Main Authors: Coughlin, Kathleen, Anchoori, Ravi, Iizuka, Yoshie, Meints, Joyce, MacNeill, Lauren, Vogel, Rachel Isaksson, Orlowski, Robert Z., Lee, Michael K., Roden, Richard BS, Bazzaro, Martina
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269153/
https://ncbi.nlm.nih.gov/pubmed/24727327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2658
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