α,β-Unsaturated Carbonyl System of Chalcone-Based Derivatives is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV)-Positive Cervical Cancer Cells

Proteasome inhibitors have potential for the treatment of cervical cancer. We describe the synthesis and biological characterization of a new series of 1,3-diphenylpropen-1-one (chalcone)-based derivatives lacking the boronic acid moieties of the previously reported chalcone-based proteasome inhibit...

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Detalhes bibliográficos
Main Authors: Bazzaro, Martina, Anchoori, Ravi K, Mudiam, Mohana Krishna R, Issaenko, Olga, Kumar, Srinivas, Karanam, Balasubramanyam, Lin, Zhenhua, Vogel, Rachel Isaksson, Gavioli, Riccardo, Destro, Federica, Ferretti, Valeria, Roden, Richard BS, Khan, Saeed R
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204583/
https://ncbi.nlm.nih.gov/pubmed/21186794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100589p
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