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Combination of proteasome and HDAC inhibitors for therapy of uterine cervical cancer

PURPOSE: Cervical cancer cells are addicted to the expression of Human Papillomavirus (HPV) oncoproteins E6 and E7. The oncogencity of E6 is mediated in part by targeting p53 and PDZ-family tumor suppressor proteins for rapid proteasomal degradation, whereas E7 oncoprotein acts in part by co-opting...

詳細記述

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書誌詳細
主要な著者: Lin, Zhenhua, Bazzaro, Martina, Wang, Mei-Cheng, Chan, Kwun C, Peng, Shiwen, Roden, Richard BS
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714480/
https://ncbi.nlm.nih.gov/pubmed/19147762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1813
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