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Structure-guided U2AF(65) variant improves recognition and splicing of a defective pre-mRNA
Purine interruptions of polypyrimidine (Py) tract splice site signals contribute to human genetic diseases. The essential splicing factor U2AF(65) normally recognizes a Py tract consensus sequence preceding the major class of 3′ splice sites. We found that neurofibromatosis- or retinitis pigmentosa-...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4267390/ https://ncbi.nlm.nih.gov/pubmed/25422459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412743111 |
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