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Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells

Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown. Here, we report that Foxd3 suppresses differentiation induced by calcineurin–NFAT signaling to maintain the ESC identity. Mecha...

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Dades bibliogràfiques
Publicat a:EMBO Rep
Autors principals: Zhu, Lili, Zhang, Shiyue, Jin, Ying
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264931/
https://ncbi.nlm.nih.gov/pubmed/25378483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438643
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