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Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chen, Jianchung, Zhou, Hairu, Diacovo, Alexander, Zheng, X. Long, Emsley, Jonas, Diacovo, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263987/
https://ncbi.nlm.nih.gov/pubmed/25293780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569392
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