Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo

Botrocetin (bt)-facilitated binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein (GP) Ib-IX-V complex on platelets in suspension initiates a signaling cascade that causes αIIbβ3 activation and platelet aggregation. Previous work has demonstrated that bt/VWF-mediated agglutina...

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Autores principales: Liu, Junling, Fitzgerald, Malinda E., Berndt, Michael C., Jackson, Carl W., Gartner, T. Kent
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Materias:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895591/
https://ncbi.nlm.nih.gov/pubmed/16788103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-011817
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