Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain...

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Bibliographic Details
Published in:Blood
Main Authors: Chen, Jianchung, Zhou, Hairu, Diacovo, Alexander, Zheng, X. Long, Emsley, Jonas, Diacovo, Thomas G.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263987/
https://ncbi.nlm.nih.gov/pubmed/25293780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569392
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