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Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Chen, Jianchung, Zhou, Hairu, Diacovo, Alexander, Zheng, X. Long, Emsley, Jonas, Diacovo, Thomas G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263987/
https://ncbi.nlm.nih.gov/pubmed/25293780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569392
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