Alterations in platelet secretion differentially affect thrombosis and hemostasis

We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Joshi, Smita, Banerjee, Meenakshi, Zhang, Jinchao, Kesaraju, Akhil, Pokrovskaya, Irina D., Storrie, Brian, Whiteheart, Sidney W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134224/
https://ncbi.nlm.nih.gov/pubmed/30185436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018019166
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