Alterations in platelet secretion differentially affect thrombosis and hemostasis

We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2...

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Publicado en:Blood Adv
Autores principales: Joshi, Smita, Banerjee, Meenakshi, Zhang, Jinchao, Kesaraju, Akhil, Pokrovskaya, Irina D., Storrie, Brian, Whiteheart, Sidney W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2018
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134224/
https://ncbi.nlm.nih.gov/pubmed/30185436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018019166
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