Src family tyrosine kinase Lyn mediates VWF/GPIb-IX–induced platelet activation via the cGMP signaling pathway

The platelet receptor for von Willebrand factor (VWF), glycoprotein (GP) Ib-IX, mediates initial platelet adhesion and transmits signals leading to platelet activation. Src family tyrosine kinases (SFKs) play an important role in VWF-induced GPIb-IX signaling. However, the SFK-dependent downstream s...

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Bibliographic Details
Main Authors: Yin, Hong, Liu, Junling, Li, Zhenyu, Berndt, Michael C., Lowell, Clifford A., Du, Xiaoping
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515128/
https://ncbi.nlm.nih.gov/pubmed/18550847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-140970
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