The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice

ER-resident proteins destined for degradation are dislocated into the cytosol by components of the ER quality control machinery for proteasomal degradation. Dislocation substrates are ubiquitylated in the cytosol by E2 ubiquitin-conjugating/E3 ligase complexes. UBE2J1 is one of the well-characterize...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Koenig, Paul-Albert, Nicholls, Peter K., Schmidt, Florian I., Hagiwara, Masatoshi, Maruyama, Takeshi, Frydman, Galit H., Watson, Nicki, Page, David C., Ploegh, Hidde L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263858/
https://ncbi.nlm.nih.gov/pubmed/25320092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604132
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