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Post-transcriptional regulation of glycoprotein quality control in the endoplasmic reticulum is controlled by the E2 Ub-conjugating enzyme UBC6e

Endoplasmic reticulum-associated degradation (ERAD) is essential for protein quality control in the ER, not only when the ER is stressed, but also at steady state. We report a new layer of homeostatic control, in which ERAD activity itself is regulated post-transcriptionally and independently of the...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hagiwara, Masatoshi, Ling, Jingjing, Koenig, Paul-Albert, Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010495/
https://ncbi.nlm.nih.gov/pubmed/27570074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.014
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