Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

The persistence of HIV-Infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five in...

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Bibliografiska uppgifter
I publikationen:Science
Huvudupphovsmän: Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., Coffin, J. M., Hughes, S. H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262401/
https://ncbi.nlm.nih.gov/pubmed/24968937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254194
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