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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal toxin (LT) in mouse macrophages from sensitive strains such as BALB/c. Upon e...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4260594/ https://ncbi.nlm.nih.gov/pubmed/25404286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415756111 |
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