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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
Activation of the cysteine protease Caspase-1 is a key event in the innate immune response to infections. Synthesized as a pro-protein, Caspase-1 undergoes autoproteolysis within multi-protein complexes called inflammasomes. Activated Caspase-1 is required for proteolytic processing and release of t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016200/ https://ncbi.nlm.nih.gov/pubmed/21147462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.11.007 |
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