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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal toxin (LT) in mouse macrophages from sensitive strains such as BALB/c. Upon e...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4260594/ https://ncbi.nlm.nih.gov/pubmed/25404286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415756111 |
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