An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the bloodstream...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260588/
https://ncbi.nlm.nih.gov/pubmed/25406323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417717111
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