An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the bloodstream...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260588/
https://ncbi.nlm.nih.gov/pubmed/25406323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417717111
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