An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the bloodstream...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260588/
https://ncbi.nlm.nih.gov/pubmed/25406323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417717111
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