An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the bloodstream...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260588/
https://ncbi.nlm.nih.gov/pubmed/25406323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417717111
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