Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL

The ALOX5 gene encodes 5-lipoxygenase (5-LO), a key enzyme of inflammatory reactions, which is transcriptionally activated by trichostatin A (TSA). Physiologically, 5-LO expression is induced by calcitriol and/or transforming growth factor-β. Regulation of 5-LO mRNA involves promoter activation and...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Ahmad, K, Katryniok, C, Scholz, B, Merkens, J, Löscher, D, Marschalek, R, Steinhilber, D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259963/
https://ncbi.nlm.nih.gov/pubmed/25402609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.39
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