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Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL
The ALOX5 gene encodes 5-lipoxygenase (5-LO), a key enzyme of inflammatory reactions, which is transcriptionally activated by trichostatin A (TSA). Physiologically, 5-LO expression is induced by calcitriol and/or transforming growth factor-β. Regulation of 5-LO mRNA involves promoter activation and...
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| Udgivet i: | Oncogenesis |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4259963/ https://ncbi.nlm.nih.gov/pubmed/25402609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.39 |
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