A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression

Tissue inhibitors of metalloproteinases 3 (TIMP3) were originally characterized as inhibitors of matrix metalloproteinases (MMPs), acting as potent antiangiogenic proteins. In this study, we demonstrated that the arylsulfonamide derivative MPT0G013 has potent antiangiogenic activities in vitro and i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Chih-Ya, Liou, Jing-Ping, Tsai, An-Chi, Lai, Mei-Jung, Liu, Yi-Min, Lee, Hsueh-Yun, Wang, Jing-Chi, Pan, Shiow-Lin, Teng, Che-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259441/
https://ncbi.nlm.nih.gov/pubmed/25226613
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