Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase

Sphingomyelinase (SMase) activity is elevated in inflammatory states and may contribute to muscle weakness in these conditions. Exogenous SMase depresses muscle force in an oxidant-dependent manner. However, the pathway stimulated by SMase that leads to muscle weakness is unclear. In non-muscle cell...

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Bibliographic Details
Published in:Respir Physiol Neurobiol
Main Authors: Bost, Elaina R., Frye, Gregory S., Ahn, Bumsoo, Ferreira, Leonardo F.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259017/
https://ncbi.nlm.nih.gov/pubmed/25448394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2014.10.011
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