NAD(P)H oxidase subunit p47(phox) is elevated, and p47(phox) knockout prevents diaphragm contractile dysfunction in heart failure

Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance, which are caused in part by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormal...

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發表在:Am J Physiol Lung Cell Mol Physiol
Main Authors: Ahn, Bumsoo, Beharry, Adam W., Frye, Gregory S., Judge, Andrew R., Ferreira, Leonardo F.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2015
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556931/
https://ncbi.nlm.nih.gov/pubmed/26209274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00176.2015
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