NAD(P)H oxidase subunit p47(phox) is elevated, and p47(phox) knockout prevents diaphragm contractile dysfunction in heart failure

Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance, which are caused in part by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormal...

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Gepubliceerd in:Am J Physiol Lung Cell Mol Physiol
Hoofdauteurs: Ahn, Bumsoo, Beharry, Adam W., Frye, Gregory S., Judge, Andrew R., Ferreira, Leonardo F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556931/
https://ncbi.nlm.nih.gov/pubmed/26209274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00176.2015
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