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NAD(P)H oxidase subunit p47(phox) is elevated, and p47(phox) knockout prevents diaphragm contractile dysfunction in heart failure

Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance, which are caused in part by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormal...

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Dades bibliogràfiques
Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Ahn, Bumsoo, Beharry, Adam W., Frye, Gregory S., Judge, Andrew R., Ferreira, Leonardo F.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556931/
https://ncbi.nlm.nih.gov/pubmed/26209274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00176.2015
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