NAD(P)H oxidase subunit p47(phox) is elevated, and p47(phox) knockout prevents diaphragm contractile dysfunction in heart failure

Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance, which are caused in part by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormal...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Ahn, Bumsoo, Beharry, Adam W., Frye, Gregory S., Judge, Andrew R., Ferreira, Leonardo F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556931/
https://ncbi.nlm.nih.gov/pubmed/26209274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00176.2015
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