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Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase

Sphingomyelinase (SMase) activity is elevated in inflammatory states and may contribute to muscle weakness in these conditions. Exogenous SMase depresses muscle force in an oxidant-dependent manner. However, the pathway stimulated by SMase that leads to muscle weakness is unclear. In non-muscle cell...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Respir Physiol Neurobiol
Prif Awduron: Bost, Elaina R., Frye, Gregory S., Ahn, Bumsoo, Ferreira, Leonardo F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259017/
https://ncbi.nlm.nih.gov/pubmed/25448394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2014.10.011
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