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Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase

Sphingomyelinase (SMase) activity is elevated in inflammatory states and may contribute to muscle weakness in these conditions. Exogenous SMase depresses muscle force in an oxidant-dependent manner. However, the pathway stimulated by SMase that leads to muscle weakness is unclear. In non-muscle cell...

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Bibliografische gegevens
Gepubliceerd in:Respir Physiol Neurobiol
Hoofdauteurs: Bost, Elaina R., Frye, Gregory S., Ahn, Bumsoo, Ferreira, Leonardo F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259017/
https://ncbi.nlm.nih.gov/pubmed/25448394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2014.10.011
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