Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc tra...

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Vydáno v:Haematologica
Hlavní autoři: Jiang, Xin, Guo, Honggang, Wu, Jianguo, He, Qiang, Li, Yiqiao, Wang, Miao, Pan, Hongyang, Li, Wande, Wang, Jinjie, Wang, Qingqing, Shen, Jing, Ke, Yuehai, Zhou, Ren
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258751/
https://ncbi.nlm.nih.gov/pubmed/25193962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.106401
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