Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc tra...

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Detaylı Bibliyografya
Yayımlandı:Haematologica
Asıl Yazarlar: Jiang, Xin, Guo, Honggang, Wu, Jianguo, He, Qiang, Li, Yiqiao, Wang, Miao, Pan, Hongyang, Li, Wande, Wang, Jinjie, Wang, Qingqing, Shen, Jing, Ke, Yuehai, Zhou, Ren
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2014
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258751/
https://ncbi.nlm.nih.gov/pubmed/25193962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.106401
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