Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc tra...

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Bibliografiset tiedot
Julkaisussa:Haematologica
Päätekijät: Jiang, Xin, Guo, Honggang, Wu, Jianguo, He, Qiang, Li, Yiqiao, Wang, Miao, Pan, Hongyang, Li, Wande, Wang, Jinjie, Wang, Qingqing, Shen, Jing, Ke, Yuehai, Zhou, Ren
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ferrata Storti Foundation 2014
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258751/
https://ncbi.nlm.nih.gov/pubmed/25193962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.106401
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