The Truncate Mutation of Notch2 Enhances Cell Proliferation through Activating the NF-κB Signal Pathway in the Diffuse Large B-Cell Lymphomas

The Notch2 is a critical membrane receptor for B-cell functions, and also displays various biological roles in lymphoma pathogenesis. In this article, we reported that 3 of 69 (4.3%) diffuse large B-cell lymphomas (DLBCLs) exhibited a truncate NOTCH2 mutation at the nucleotide 7605 (G/A) in the cDNA...

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Hlavní autoři: Zhang, Xinxia, Shi, Yaoyao, Weng, Yuanyuan, Lai, Qian, Luo, Taobo, Zhao, Jing, Ren, Guoping, Li, Wande, Pan, Hongyang, Ke, Yuehai, Zhang, Wei, He, Qiang, Wang, Qingqing, Zhou, Ren
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196756/
https://ncbi.nlm.nih.gov/pubmed/25314575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108747
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