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The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells
BACKGROUND: Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex that plays an important role in hematopoietic differentiation. Therefore, we hypot...
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| Publicado no: | Cell Mol Biol Lett |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6085606/ https://ncbi.nlm.nih.gov/pubmed/30116272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11658-018-0102-4 |
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