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The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells

BACKGROUND: Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex that plays an important role in hematopoietic differentiation. Therefore, we hypot...

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Bibliografski detalji
Izdano u:Cell Mol Biol Lett
Glavni autori: Wu, Wei, Nie, Li, Zhang, Li, Li, Yan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085606/
https://ncbi.nlm.nih.gov/pubmed/30116272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11658-018-0102-4
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