Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis

SHP-2 (PTPN11), a ubiquitously expressed protein tyrosine phosphatase, is critical for hematopoietic cell development and function owing to its essential role in growth factor/cytokine signaling. More importantly, germline and somatic mutations in this phosphatase are associated with Noonan syndrome...

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Bibliographic Details
Main Authors: Liu, Xia, Qu, Cheng-Kui
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2011
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135119/
https://ncbi.nlm.nih.gov/pubmed/21799948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/195239
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