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Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11- Associated Malignancies

Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias. Identification of SHP2 selective inhibitors coul...

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Autores principales: Yu, Bing, Liu, Wei, Yu, Wen-Mei, Loh, Mignon L., Alter, Shawn, Guvench, Olgun, MacKerell, Alexander D., Tang, Li-Da, Qu, Cheng-Kui
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769526/
https://ncbi.nlm.nih.gov/pubmed/23825065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0049-T
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