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Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase
The SHP2 phosphatase plays a central role in a number of signaling pathways were it dephosphorylates various substrate proteins. Regulation of SHP2 activity is, in part, achieved by an intramolecular interaction between the PTP domain of the protein, which contains the catalytic site, and the N-SH2...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076527/ https://ncbi.nlm.nih.gov/pubmed/21365683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22984 |
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